Hashemi 2012.

Study characteristics
Methods	Study design: split‐mouth RCT Conducted in: Tehran, Iran Number of centres: 1 (Tehran University Hospital) Recruitment period: September 2008 to January 2010
Participants	Inclusion criteria: bilateral bony mandibular third molars that were fairly similar in terms of angulation, degree of impaction, and estimated difficulty of removal Exclusion criteria: presence of any medical problem that would contraindicate extraction, pathological lesion near teeth to be extracted Number randomised: 30 Number evaluated: 30
Interventions	No sutures versus multiple sutures for wound closure Group A (n = 30 teeth) Group B (n = 30 teeth) Follow‐up: 7 days All procedures were carried out by a single surgeon under local anaesthetic.
Outcomes	Pain (0‐to‐5 VAS) and swelling on days 1, 3, and 7
Notes	Sample size calculation: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "...one of the two impacted mandibular third molars in each patient was randomly allocated" Comment: method of sequence generation not described
Allocation concealment (selection bias)	Unclear risk	No mention of who conducted the randomisation and whether it was concealed from the surgeon.
Blinding (performance bias and detection bias) patient	Unclear risk	Not possible
Blinding (performance bias and detection bias) assessor	High risk	Not mentioned
Incomplete outcome data (attrition bias) All outcomes	Low risk	It appears that all the randomised participants were included in the outcome valuation.
Selective reporting (reporting bias)	High risk	Planned outcomes reported, but it is unclear if paired nature of data was taken into account.
Other bias	Low risk	No other sources of bias identified.