Kapse 2019.

Study characteristics
Methods	Study design: split‐mouth RCT Conducted in: India
Participants	Inclusion criteria: patients with normal haematologic profiles, no systemic illness, good oral hygiene, and surgical site free of active infection Exclusion criteria: use of tobacco or alcohol during the study period and unwillingness to attend the long‐term follow‐up programme Age: 18 to 40 years Number randomised: 30 participants/60 sites Number evaluated: 30 participants/60 sites
Interventions	Platelet‐rich fibrin in extraction socket versus none Group A: test group (n = 30 site) PRF placed in the extraction socket Group B: control (n = 30 site) The time interval between extractions of M3 in a participant was 30 days. All procedures were performed under local anaesthesia, braided, black silk suture was used.
Outcomes	Pain (0‐to‐10 VAS), swelling, and bone healing (radiographical assessment)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Comment: participants were randomly assigned numbers and were categorised into groups
Allocation concealment (selection bias)	Unclear risk	Comment: method of concealment of the allocations was not clearly stated
Blinding (performance bias and detection bias) patient	Unclear risk	Comment: it is not explicitly stated
Blinding (performance bias and detection bias) assessor	Low risk	Comment: all of the evaluations were carried out by investigators other than the operating surgeon
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: no dropouts
Selective reporting (reporting bias)	Low risk	All planned outcomes were reported.
Other bias	Low risk	No other sources of bias identified.