Uyanik 2015.
| Study characteristics | ||
| Methods | Study design: split‐mouth RCT Conducted in: Nicosia, Cyprus |
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| Participants | Inclusion criteria: (a) the presence of bilateral, symmetrically oriented, impacted lower third molars requiring extraction for prophylactic reasons; (b) the absence of systemic diseases; (c) no chronic opioid use; (d) age > 18 years; (e) non‐smoker and non‐alcoholic; (f ) not pregnant; and (g) no allergy to penicillin or other drugs Exclusion criteria: patients taking antibiotics for a current infection, or who had acute pericoronitis or severe periodontal disease at the time of the operation and if tooth needed sectioning during the surgery Age: 19 to 31 Number randomised: 20 (10 female/10 male) Number evaluated: 20 (40 wisdom teeth) |
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| Interventions | PRF or a combination of PRF and piezosurgery versus conventional rotatory osteotomy Group A (n = 10 participants/20 teeth): traditional surgery was performed on 1 side (Group 1, n = 10); traditional surgery was performed and PRF was administered to the extracted socket on the other side of same participant (Group 2, n = 10) Group B (n = 10 participants/20 teeth): piezosurgery was used for osteotomy and PRF was administered on 1 side (Group 3, n = 10); traditional surgery was performed on the other side of same participant (Group 4, n = 10) |
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| Outcomes | Variables assessed were pain, the number of analgesics taken, trismus, and cheek swelling at baseline and on postoperative days 1, 2, 3, and 7. Pain VAS (0 to 10) Trismus (measurement of interincisal distances). |
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| Notes | Sample size calculation: not reported | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Quote: "the selection of processes of which technique to use first on each participant was randomly selected." |
| Allocation concealment (selection bias) | Unclear risk | Comment: concealment approaches were not described, and it is unclear how the randomisation was achieved |
| Blinding (performance bias and detection bias) patient | High risk | Quote: "all of the participants were informed regarding the surgical procedure, postoperative time and possible complications." Comment: the extent to which the surgical procedure was described is unclear. All participants had PRF in 1 of their extraction sites; however, as the control and experimental extractions were done on separate occasions, unless the participant had blood samples taken on both occasions they would have guessed which side had PRF. |
| Blinding (performance bias and detection bias) assessor | Unclear risk | Quote: "all of the examinations were undertaken at approximately the same time of day and by the same surgeon; measurements were always obtained by the same individual, both preoperatively and postoperatively." Comment: it is unclear if this was the operating surgeon |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: all participants included in data evaluation, no dropout |
| Selective reporting (reporting bias) | Low risk | Comment: all planned outcomes were reported |
| Other bias | Unclear risk | Comment: carry‐over effect was not evaluated |