NCT02942108.

Study name	Piezoelectric vibrations and tissue, cellular and molecular mechanisms of oral wound healing after third molar surgery
Methods	Interventional (clinical trial)
Participants	40 participants
Interventions	Randomised cross‐over/piezosurgery
Outcomes	Primary outcome measures: SOD (superoxide dismutase) activity in alveolar bone specimen (time frame: immediately after surgery). Activity of enzyme superoxide dismutase in bone specimens obtained during lower third molar surgery VEGF (vascular endothelial growth factor) levels in alveolar bone specimen (time frame: immediately after surgery) MMP‐9 (matrix metalloproteinases) level in alveolar bone specimen (time frame: immediately after surgery)
Starting date	October 2016
Contact information	Bozidar M Brkovic, DDS, PhD
Notes	2nd Principal Investigator Marija S Milic, DDS, PhD

PRP: platelet rich plasma; PRF: platelet rich fibrin; RCT: randomised controlled trial