Search terms

Unless otherwise stated, search terms were free text terms; exp = exploded MeSH: Medical Subject Heading (Medline medical index term); the dollar sign ($) stands for any character(s); the question mark (?) = substitute for one or no characters; ab = abstract; ti = titel; ot = original titel; pt = publication type; sh = MeSH: Medical subject heading (MEDLINE medical index term); adj = adjacency. I. Metformin: 1.exp Biguanides/ 2.(metformin$ or glucophag$ or biguanid$).ab,ti,ot. 3.1 or 2 II. Insulin therapy: 4.Insulin/ad, aa, tu, th [Administration & Dosage, Analogs & Derivatives, Therapeutic Use, Therapy] 5.(insulin$ adj6 (therap$ or treatment$ or intervention$)).ab,ti,ot. 6.4 or 5 III. Diabetes mellitus: 7.exp diabetes mellitus/ 8.diabet$.ab,ti,ot. 9.(IDDM or NIDDM or MODY or T1DM or T2DM).ab,ti,ot. 10.((typ$ 1 or typ$ 2) and diabet$).ab,ti,ot. 11.((typ$ I or typ$ II) and diabet$).ab,ti,ot. 12.insulin$ secret$ dysfunc$.ab,ti,ot. 13.impaired glucose toleran$.ab,ti,ot. 14.exp Glucose Intolerance/ 15.glucose intoleran$.ab,ti,ot. 16.exp Insulin Resistance/ 17.insulin$ resist$.ab,ti,ot. 18.(non insulin$ depend$ or noninsulin$ depend$ or non insulin?depend$ or noninsulin?depend$).ab,ti,ot. 19.(insulin$ depend$ or insulin?depend$).ab,ti,ot. 20.metabolic$ syndrom$.ab,ti,ot. 21.(pluri metabolic$ syndrom$ or plurimetabolic$ syndrom$).ab,ti,ot. 22.(late onset adj diabet$).ab,ti,ot. 23.(maturity onset adj diabet$).ab,ti,ot. 24.(juvenile adj diabet$).ab,ti,ot. 25.(syndrome X and diabet$).ab,ti,ot. 26.hyperinsulin$.ab,ti,ot. 27.insulin sensitiv$.ab,ti,ot. 28.or/7‐27 29.exp diabetes insipidus/ 30.diabet$ insipidus.ab,ti,ot. 31.29 or 30 32.28 not 31 IV. RCT/CCT (sensitive search): Part 1: 33.randomized controlled trial.pt. 34.controlled clinical trial.pt. 35.randomized controlled trials.sh. 36.random allocation.sh. 37.double‐blind method.sh. 38.single‐blind method.sh. 39.or/33‐38 Part 2: 40.clinical trial.pt. 41.exp clinical trials/ 42.(clinic$ adj25 trial$).ab,ti,ot. 43.((singl$ or doubl$ or trebl$ or tripl$) adj (mask$ or blind$)).ab,ti,ot. 44.placebos.sh. 45.placebo$.ab,ti,ot. 46.random$.ab,ti,ot. 47.research design.sh. 48.(latin adj square).ab,ti,ot. 49.or/40‐48 Part 3: 50.comparative study.pt. 51.exp evaluation studies/ 52.follow‐up studies.sh. 53.prospective studies.sh. 54.(control$ or prospectiv$ or volunteer$).ab,ti,ot. 55.cross‐over studies.sh. 56.or/50‐55 57.39 or 49 or 56 V. Meta‐analysis: 58.exp meta‐analysis/ 59.exp Review Literature/ 60.meta‐analysis.pt. 61.review.pt. 62.or/58‐61 63.letter.pt. 64.comment.pt. 65.editorial.pt. 66.historical‐article.pt. 67.or/63‐66 68.62 not 67 69.((systematic$ or quantitativ$ or methodologic$) adj (review$ or overview$)).ab,ti,ot. 70.meta?anal$.ab,ti,ot. 71.(integrativ$ research review$ or research integration$).ab,ti,ot. 72.quantitativ$ synthes$.ab,ti,ot. 73.(pooling$ or pooled analys$ or mantel$ haenszel$).ab,ti,ot. 74.(peto$ or der?simonian$ or fixed effect$ or random effect$).ab,ti,ot. 75.or/69‐74 76.68 or 75 VI. HTA: 77.exp Technology Assessment, Biomedical/ 78.HTA.ab,ti,ot. 79.(health technology adj6 assessment$).ab,ti,ot. 80.(biomedical adj6 technology assessment$).ab,ti,ot. 81.or/77‐80 VII. Metformin + Insulin + Diabetes mellitus: 82.3 and 6 and 32 VIII. RCT/CCT + Meta‐analysis + HTA: 83.57 or 76 or 81 IX. VII + VIII: 84.82 and 83 X. Polycystic ovary syndrome (excluded): 85.exp Polycystic Ovary Syndrome/ 86.84 not 85 XI. Adolescent: 87.exp Adolescent/ 88.exp Puberty/ 89.(adolescent$ or pubert$).ab,ti,ot. 90.or/87‐89 91. 86 and 90 92. limit 91 to animal 93. limit 91 to human 94. 92 not 93 95. 91 not 94