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. 2009 Apr 15;2009(2):CD006712. doi: 10.1002/14651858.CD006712.pub2

Comparison 6. General anesthesia.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Postoperative pain comparing halothane and alfentanil 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
2 Postoperative pain comparing thiopental and fentanyl with thiopental and halothane 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
3 Postoperative pain comparing thiopental and fentanyl with thiopental and enflurane 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
4 Postoperative pain comparing trichlorethylen with total IV (methohexital) anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
5 Blood loss (ml) comparing inhalational anesthetics with opiates 2   Mean Difference (IV, Random, 95% CI) Totals not selected
5.1 comparing halothane with alfentanil 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 comparing enflurane with fentanyl 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 Anesthetic complications comparing halothane and alfentanil 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
7 Side effects comparing enflurane with fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
7.1 Severe anesthetic complications comparing enflurane with fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.2 Nausea and vomiting comparing enflurane with fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Side effects comparing trichloethylene with total IV anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
8.1 Lanryngospasm comparing trichloethylene with total IV anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 Pain on induction comparing trichloethylene with total IV anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.3 Nausea comparing trichloethylene with total IV anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.4 Vomiting comparing trichloethylene with total IV anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.5 Intraoperative involuntary muscle movement comparing trichloethylene with total IV anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Recovery time (min.) comparing inhalation anesthetics with opiates 2   Mean Difference (IV, Random, 95% CI) Totals not selected
9.1 Recovery time (min.) comparing halothane and alfentanil 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9.2 Recovery time (min.) comparing enflurane with fentanyl 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10 Postoperative pain comparing propofol with etomidate 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
11 Postoperative pain comparing propofol with thiopental 3 350 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.11 [0.61, 2.02]
11.1 Alfentanil 2 140 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.20 [0.52, 2.75]
11.2 Fentanyl 2 210 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.02 [0.43, 2.42]
12 Postoperative pain comparing propofol with methohexital 2 140 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.42 [0.16, 1.12]
12.1 Alfentanil 1 40 Peto Odds Ratio (Peto, Fixed, 95% CI) 7.79 [0.47, 129.11]
12.2 Fentanyl 1 100 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.28 [0.10, 0.80]
13 Postoperative pain comparing propofol and fentanyl with midazolam and fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
14 Postoperative pain comparing propofol and alfentanil with ketamine and midazolam 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
14.1 Ketamine 0.5mg/kg and midazolam 0.25mg/kg 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
14.2 Ketamine 1mg/kg and midazolam 0.1mg/kg 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
15 Postoperative pain comparing propofol and ketamine with propofol and fentanyl 2 180 Peto Odds Ratio (Peto, Fixed, 95% CI) 4.66 [2.16, 10.06]
16 Postoperative pain comparing thiopental and fentanyl with ketamine and diazepam 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
17 Postoperative pain comparing propofol and alfentanil with propofol 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
18 Postoperative pain comparing placebo with alfentanil and fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
18.1 Alfentanil 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
18.2 Fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
19 Postoperative pain comparing alfentanil with fentanyl when added to propofol 2 210 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.96 [1.07, 3.60]
20 Postoperative pain comparing alfentanil with fentanyl when added to thiopental 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
21 Side effects comparing propofol with other sedative hypnotic agents 6   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
21.1 Pain on injection comparing propofol with etomidate 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.2 Pain on injection comparing propofol with thiopental 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.3 Pain on injection comparing etmoidate with thiopental 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.4 Pain on injection comparing propofol with methohexital 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.5 Pain on injection comparing propofol and fentanyl with fentanyl and midazolam 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.6 Pain on injection comparing propofol and fentanyl with propofol and ketamine 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.7 Pain with injection comparing propofol and alfentanil with ketamin 1mg/kg and midazolam 0.1mg/kg 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.8 Pain with injection comparing propofol with ketamine 1mg/kg and midazolam 0.1mg/kg 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.9 Pain with injection comparing propofol with propofol and alfentanil 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.10 Apnea comparing propofol with etomidate 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.11 Apnea comparing propofol with thiopental 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.12 Apnea comparing etomidate with thiopental 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.13 Apnea comparing propofol with methohexital 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.14 Muscle movements comparing propofol with etomidate 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.15 Muscle movements comparing propofol with thiopental 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.16 Muscle movements comparing etomidate with thiopental 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.17 Muscle movements comparing propofol with methohexital 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.18 Intraoperative movement comparing thiopental and fentanyl with ketamine and diazepam 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.19 Intraoperative movement comparing thiopental and fentanyl with thiopental and halothane 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.20 Intraoperative movement comparing ketamine and diazepam with thiopental and halothane 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.21 Movement with cervical dilation comparing propofol with ketamin 1mg/kg and midazolam 0.1mg/kg 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.22 Movement with cervical dilation comparing propofol and alfentanil with ketamin 1mg/kg and midazolam 0.1mg/kg 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.23 Movement with cervical dilation comparing propofol with propofol and alfentanil 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.24 Nausea comparing propofol and fentanyl with thiopental and fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.25 Nausea comparing propofol and alfentanil/fentanyl with methohexital and alfentanil/fentanyl 2   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.26 Nausea comparing propofol and fentanyl with propofol and ketamine 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.27 Nausea comparing propofol and fentanyl with midazolam and fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.28 Nausea comparing thiopental and fentanyl with ketamine and diazepam 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.29 Nausea comparing thiopental and fentanyl with thiopental and enflurane 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.30 Nausea comparing thiopental and fentanyl with thiopental and halothane 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.31 Nausea comparing ketamine and diazepam with thiopental and halothane 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.32 Nausea comparing ketamine and diazepam with thiopental and enflurane 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.33 Vomiting comparing propofol and fentanyl with propofol and ketamine 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.34 Vomiting comparing propofol and fentanyl with midazolam and fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.35 Vomiting comparing propofol and alfentanil with ketamine 1mg/kg and midazolam 0.1mg/kg 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.36 Dreams comparing propofol and ketamine with propofol and fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.37 Dreams comparing propofol and ketamine with propofol and thiopental 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.38 Dreams comparing propofol and ketamine with propofol and methohexital 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.39 Hallucinations comparing propofol and fentanyl with propofol and ketamine 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.40 Hallucinations comparing fentanyl and midazolam with propofol and ketamine 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22 Side effects comparing propofol and placebo with propofol and either alfentanil or fentanyl 2   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
22.1 Nausea comparing alfentanil with placebo 2   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.2 Nausea comparing fentanyl with placebo 2   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.3 Nausea comparing alfentanil with fentanyl 2   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.4 Vomiting comparing alfentanil with placebo 2   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.5 Vomiting comparing fentanyl with placebo 2   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.6 Vomiting comparing alfentanil with fentanyl 2   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.7 No complications comparing alfentanil with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.8 No complications comparing fentanyl with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.9 No complications comparing alfentanil with fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.10 Laryngospasm or difficulty ventilating comparing alfentanil with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.11 Laryngospasm or difficulty ventilating comparing fentanyl with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.12 Laryngospasm or difficulty ventilating comparing alfentanil with fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
23 Time to discharge 3   Mean Difference (IV, Random, 95% CI) Subtotals only
23.1 Time to discharge (min.) comparing propofol with thiopental 2 200 Mean Difference (IV, Random, 95% CI) ‐14.69 [‐24.95, ‐4.43]
23.2 Time to discharge (min.) comparing propofol and placebo with propofol and alfentanil 1 104 Mean Difference (IV, Random, 95% CI) ‐9.0 [‐24.87, 6.87]
23.3 Time to discharge (min.) comparing propofol and placebo with propofol and fentanyl 1 104 Mean Difference (IV, Random, 95% CI) 2.0 [‐16.50, 20.50]
24 Pain with dilation comparing conscious sedation and PCB with general anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
25 Pain with aspiration comparing conscious sedation and PCB with general anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
26 Postoperative pain comparing conscious sedation and PCB with general anesthesia 1   Mean Difference (IV, Random, 95% CI) Totals not selected
27 Apnea incidence comparing conscious sedation and PCB with genereal anesthesia 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
28 Duration of sleep (min.) comparing conscious sedation and PCB with general anesthesia 1   Mean Difference (IV, Random, 95% CI) Totals not selected