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. 2009 Apr 15;2009(2):CD006712. doi: 10.1002/14651858.CD006712.pub2

Comparison 7. General anesthesia with premedication.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Postoperative pain comparing paracetamol supp with placebo 1   Mean Difference (IV, Random, 95% CI) Totals not selected
1.1 30 minutes postoperatively 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.2 1 hour postoperatively 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.3 At discharge 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
2 Postoperative pain comparing paracetamol/codeine supp with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
2.1 30 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.2 60 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.3 at discharge 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 Postoperative pain comparing paracetamol po with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
4 Postoperative pain comparing paracetamol po with lornoxicam 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
5 Postoperative pain comparing diclofenac with ketorolac and with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
5.1 Diclofenac po versus NaCL 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 Diclofenac im versus NaCL 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.3 Ketorolac im versus NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.4 Diclofenac po versus ketorolac im 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.5 Diclofenac im versus ketorolac im 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Postoperative pain comparing etoricoxib with placebo 1   Mean Difference (IV, Random, 95% CI) Totals not selected
6.1 15 minutes postoperatively 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.2 30 minutes postoperatively 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.3 60 minutes postoperatively 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.4 at discharge 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7 Side effects comparing COX inhibitors with placebo as premedication for general anesthesia 4   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
7.1 Antiemetic requirements comparing paracetamol supp with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.2 Antiemetic requirements comparing paracetamol po with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.3 Antiemetic requirements comparing lornoxicam with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.4 Antiemetic requirements comparing lornoxicam with paracetamol po 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.5 Nausea comparing diclofenac po with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.6 Nausea comparing diclofenac im with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.7 Nausea comparing ketorolac im with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.8 Vomiting comparing diclofenac po with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.9 Vomiting comparing diclofenac im with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.10 Vomiting comparing ketorolac im with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.11 Anxiety during recovery comparing diclofenac po with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.12 Anxiety during recovery comparing diclofenac im with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.13 Anxiety during recovery comparing ketorolac im with NaCl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.14 Satisfaction with pain management comparing etoricoxib with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Recovery time (min.) comparing COX inhibitors with placebo as premedication for general anesthesia 4   Mean Difference (IV, Random, 95% CI) Totals not selected
8.1 Time to street fittness comparing paracetamol supp with placebo 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.2 Time to discharge comparing paracetamol po with placebo 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.3 Time to discharge comparing lornoxicam with placebo 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.4 Time to discharge comparing lornoxicam with paracetamol po 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.5 Time to discharge comparing diclofenac po with NaCl 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.6 Time to discharge comparing diclofenac im with NaCl 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.7 Time to discharge comparing ketorolac im with NaCl 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.8 Time to discharge comparing diclofenac po with ketorolac im 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.9 Time to discharge comparing diclofenac im with ketorolac im 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.10 Time to discharge comparing etoricoxib with placebo 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9 Postoperative pain comparing Nalbuphine with fentanyl 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
9.1 1 hour postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
9.2 2 hours postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
10 Recovery (reaction time (msec.)) comparing nalbuphine with fentanyl 1   Mean Difference (IV, Random, 95% CI) Totals not selected
10.1 1 hour postoperatively 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.2 2 hours postoperatively 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.3 4 hours postoperatively 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11 Side effects comparing paracetamol/codeine supp with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
11.1 Nausea at 30 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.2 Nausea at 60 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.3 Nausea at discharge 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.4 Fully awake at 30 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.5 Fully awake at 60 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.6 Sleepy at 30 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.7 Sleepy at 60 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.8 Asleep but easily arousable at 30 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.9 Asleep but easily arousable at 60 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.10 Heavily asleep at 30 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.11 Heavily asleep at 60 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
12 Recovery time (discharge ready) comparing paracetamol/codeine supp with placebo 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
12.1 Discharge ready at 30 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.2 Discharge ready at 60 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.3 Discharge ready at 90 minutes postoperatively 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]