| Methods |
Randomized controlled trial. University of Copenhagen, Denmark. |
| Participants |
60 pregnant women. Age: 18‐44 years. Healthy women. Gestational age up to 12 weeks. |
| Interventions |
Group 1: thiopental 4mg/kg
Group 2: etomidate 0.3mg/kg
Group 3: propofol 2.5mg/kg
for induction of anesthesia.
All participants: No premedication. Alfentanil 15mcg/kg after induction. Additional 1/4 of the induction anesthetic as needed. Oxytocic drugs.
All under assisted ventilation with 100% oxygen with a face mask. |
| Outcomes |
Postoperative side ffects including pain (yes/no) and vomiting.
Dosage requirements. Vital signs. Pain on injection of anesthetic. Recovery: Steward score, coin counting test (CCT), continuous auditory reaction time test (CART). Need for postoperative analgesics. Other side effects: apnea, involuntary muscle movements. |
| Notes |
No power calculations. Unclear study length, method of randomization and allocation concealment. Unclear if the procedure was vacuum versus sharp curettage. The author could not be succeessfully contacted to clarify unclear information.
Outcome assessor was blinded.
Apnea occured in 9, 1 and 3 patients of the propofol, etomidate and thiopental group respectively. There was no significant diffference. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
