| Methods |
Randomized controlled double blind trial. Nurse otherwise not involved in study drew the randomized envelope.
Karolinska Institute at Danderyds Hospital, Denderyd, Sweden. |
| Participants |
140 pregnant women. ASA I‐II group. Elective termination of pregnancy. |
| Interventions |
Group 1: 1gm paracetamol suppository.
Group 2: placebo suppository.
All participants: no premedication. Induction of anesthesia with 0.1mg fentanyl and propofol. Maintenance with nitrous oxide in oxygen 2:1 and additional small doses of propofol as needed. Spontaneous breathing, assisted ventilation as needed. 5 units oxytocin at the end of the procedure.
All patients: Vacuum aspiration.
Rescue medication for postoperative pain diclofenac 100mg supp. |
| Outcomes |
Postoperative pain measured with a 10cm visual analog scale (0cm=no pain, 10cm=unbearable pain), measured 30 and 60 minutes postoperatively and at discharge. Analgesic and antiemetic requirements. Time until street fittness. |
| Notes |
Per e‐mail communication with Dr. Jakobsson: Gestational age 7‐12 weeks. Computer‐based randomization with envelopes. The study lasted over 2.5 months.
All procedures were uneventful and no complications were noted. No industry sponsorship. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
High risk |
C ‐ Inadequate |
