| Methods |
Randomized controlled double blind trial. Allocation concealment with envelope technique done by a nurse otherwise not involved in study. Per power analysis 70 needed per group to achieve power of 80%.
Karolinska Institute at Danderyds Hospital, Denderyd, Sweden. |
| Participants |
210 pregnant women. ASA I‐II group. Elective termination of pregnancy. |
| Interventions |
Group 1: paracetamol 1gm per os 1 hour preoperatively.
Group 2: lornoxicam 8mg per os 1 hour preoperatively.
Group 3: placebo.
All participants: no other premedication. Induction of anesthesia with 0.1mg fentanyl and 2‐2.5mg/kg propofol. Maintenance with nitrous oxide in oxygen 2:1 and additional small doses of propofol (20‐30mg) as needed. Spontaneous breathing, assisted ventilation as needed. Some patients received laminaria preoperatively. 5 units oxytocin at the end of the procedure.
All patients: Vacuum aspiration.
Rescue medication for postoperative pain diclofenac 100mg supp. |
| Outcomes |
Postoperative pain on 100mm visual analog scale (0=no pain, 100=unbearable pain) measured at 30 and 60 minutes postoperatively and at discharge. Analgesics postoperatively. Antiemetics. Time to discharge |
| Notes |
Unclear method of randomization. For statistics pain was dichotomized. No complications noted. Per e‐mail communication gestational age 8‐13 weeks, and no industry sponsorship. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
