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. Author manuscript; available in PMC: 2020 Jul 29.
Published in final edited form as: Exp Biol Med (Maywood). 2009 Dec;234(12):1477–1483. doi: 10.3181/0904-RM-142

Table 1.

Effects of Genotype on Relative Peak Area of APAP Metabolites in Urine Collected for 24 h After APAP (300 mg/kg) Injectiona

WT GPX1−/− SOD1−/− DKO
APAP 11.3 ± 1.4 13.9 ± 3.3   9.1 ± 2.6 10.8 ± 1.7
APAP-cysteine 48.9 ± 1.5 49.2 ± 2.2 46.2 ± 4.9 51.4 ± 2.7
APAP-N-acetylcysteine   2.7 ± 0.8   4.8 ± 0.6 18.9 ± 7.0*   4.8 ± 1.5
APAP-glucuronide 37.0 ± 2.0 32.1 ± 3.2 25.7 ± 3.3* 32.9 ± 1.8
a

Values (means ± SE, n = 5) represent the relative percentage of the peak area (total = 100 for each genotype).

*

indicates P < 0.05 as compared to WT.