DOMINO.

Trial name or title	A Multi‐Center, Double‐Blind, Pilot Study of Minocycline in Huntington's Disease.
Methods	18‐month, randomised, double‐blind, parallel study.
Participants	Clinical features of HD and a confirmatory family history of HD and/or genetically confirmed HD. 18 years or older.
Interventions	Minocycline 200 mg/day vs. placebo.
Outcomes	Primary: change in TFC‐UHDRS, and to assess futility of further study of the drug. Secondary: safety/tolerability.
Starting date	January 2006.
Contact information	Huntington Study Group (1‐800‐487‐7671).
Notes