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. 2020 Jul 29;17:49. doi: 10.1186/s12987-020-00205-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Comparison of proteins detected between extracellular fluid (ECF) from brain and ventricular CSF at the time of surgery (a) with p-values listed for all detected proteins and 0.05 indicated by red line. b Spearman’s rho showing correlation for all detected proteins with lines starting at zero, indicating positive and negative correlation by right and left, respectively. a, b Circles in orange mark proteins from the immunological panel, and circles in blue mark proteins from the neurological panel. Molecular weights (kDa) are shown by numbers within coloured circles. c Spread of proteins between compared compartments based on molecular weight (kDa), where a positive standardized difference indicates higher levels in ISS samples from brain and a negative standardized difference indicates higher levels in ventricular CSF samples. d Boxplot for spread of spearman’s rho subdivided according to the two protein panels