Warren 1998.

Methods	Randomised controlled trial (6 months follow‐up)
Participants	322 adults with epilepsy and their caregivers Mean age of patient responders was 36 years; 51% were male
Interventions	Intervention: epilepsy nurse specialist providing case management and clinic appointment Control: standard care from clinic doctors
Outcomes	Patient psychosocial outcomes Psychological well‐being from postal questionnaires at 6 months Social functioning from postal questionnaires at 6 months Knowledge of epilepsy from postal questionnaires at 6 months Self management of epilepsy from postal questionnaires at 6 months Satisfaction with care from postal questionnaires at 6 months Carer psychosocial outcomes Psychological well‐being from postal questionnaires at 6 months Knowledge of epilepsy from postal questionnaires at 6 months Satisfaction with care from postal questionnaires at 6 months Medical management across the primary/secondary care interface Seizure frequency from postal questionnaires at 6 months Incidence of side effects from antiepileptic medication from postal questionnaires at 6 months Incidence of injuries from seizures from postal questionnaires at 6 months Use of epilepsy‐related services from postal questionnaires at 6 months General practitioner satisfaction with clinic care for their patient from semi‐structured telephone interview of convenience sample of GPs (time at which conducted not reported) Direct medical costs of care: data extracted from postal questionnaires at 6 months and medical records
Funding	Information on study funding not reported
Notes	Included patients with learning disabilities
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Block randomisation was centrally coordinated prior to clinician involvement
Allocation concealment (selection bias)	Low risk	Patients were allocated by sealed envelopes inserted into the case notes of eligible participants by an individual independent to the research and clinical teams. There was no obvious possibility of contamination.
Blinding (performance bias and detection bias) All outcomes	High risk	There was no blinding reported. The subjective nature of the vast majority of outcomes measured by self reported questionnaire means this may have introduced bias
Incomplete outcome data (attrition bias) All outcomes	Low risk	89% of participants completed questionnaires at the end of the study
Selective reporting (reporting bias)	Low risk	A great many outcomes were assessed by this report. There is, however, no evidence of selective reporting
Other bias	Unclear risk	Authors reported a required sample size, but it was not clear if this was the result of a power calculation
Overall risk of bias	Low risk	There was block randomisation, but no blinding and moderate levels of dropout with differences between both responders and non‐responders and between intervention and control groups. However, these differences were accounted for by statistical analysis

AED: antiepileptic drug; ESMS: Epilepsy Self Management Scale; QOLIE‐89: Quality of Life in Epilepsy Inventory; SF‐36: 36‐item Short Form Health Survey.