Section/Topic	#	Checklist item	Reported on page #
Risk of bias across studies	15	Specify any assessment of risk of bias that may affect the cumulative evidence (e.g. publication bias, selective reporting within studies)	Yes
Additional analyses	16	Describe methods of additional analyses (e.g. sensitivity or subgroup analyses, meta‐regression), if done, indicating which were prespecified	Yes
RESULTS
Study selection	17	Give numbers of studies screened, assessed for eligibility and included in the review, with reasons for exclusions at each stage, ideally with a flow diagram	Yes. In the text ‐ also "Characteristics of excluded studies"
Study characteristics	18	For each study, present characteristics for which data were extracted (e.g. study size, PICOS, follow‐up period) and provide the citations	Yes
Risk of bias within studies	19	Present data on risk of bias of each study and, if available, any outcome level assessment (see item 12)	Additional Tables 3, 4; Appendices 4, 5
Results of individual studies	20	For all outcomes considered (benefits or harms), present, for each study, the following: (a) simple summary data for each intervention group, and (b) effect estimates and confidence intervals, ideally with a forest plot	Tables of "Characteristics of included studies"
Synthesis of results	21	Present results of each meta‐analysis done, including confidence intervals and measures of consistency	N/A
Risk of bias across studies	22	Present results of any assessment of risk of bias across studies (see Item 15)	Summary of findings tables
Additional analysis	23	Give results of additional analyses, if done (e.g. sensitivity or subgroup analyses, meta‐regression [see Item 16])	Tables 6 to 10
DISCUSSION
Summary of evidence	24	Summarise the main findings including strength of the evidence for each main outcome; consider their relevance to key groups (e.g. healthcare providers, users and policy makers)	Yes
Limitations	25	Discuss limitations at study and outcome levels (e.g. risk of bias) and at review level (e.g. incomplete retrieval of identified research, reporting bias)	Yes
Conclusions	26	Provide a general interpretation of the results in the context of other evidence, and implications for future research	Yes
FUNDING
Funding	27	Describe sources of funding for the systematic review and other support (e.g. supply of data); the role of funders for the systematic review	Yes