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. 2020 May 29;2020(5):CD012947. doi: 10.1002/14651858.CD012947.pub2

Choudhari 2019b.

Study characteristics
Patient Sampling Cross‐sectional study. Phakic participants aged 40 years or older attending a rural eye clinic were examined between June 2001 and January 2003. Data from the right eye were included in the analysis.
Patient characteristics and setting Sample size: 888 eyes (271 narrow angle and 617 open angle).
Age: median 50 IQR (45‐60).
Sex: 497 (55.9%) female.
Setting: community.
Country: India.
Ethnicity: Indian.
Exclusions: abnormalities that would preclude visualisation of the peripheral ACD, aphakia, pseudophakia, manifest strabismus or insufficient co‐operation.
Index tests LACD: original van Herick grading scheme used (grade 1‐4) performed at the temporal angle. Grade 2 or less was used as the cut‐off (≤ 25%).
Target condition and reference standard(s) Indentation gonioscopy was performed in dim illumination. An occludable angle was defined as the posterior trabecular meshwork not visible in 2 or more quadrants (≥ 180 degrees).
Flow and timing There were no participants that were excluded or had uninterpretable results. The index test and reference standard were conducted on the same occasion.
Comparative  
Notes Conflict of interest: no conflict of interest statement provided.
Methodological quality
Item Authors' judgement Risk of bias Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled? Yes    
Was a case‐control design avoided? Yes    
Did the study avoid inappropriate exclusions? Yes    
Could the selection of patients have introduced bias?   Low risk  
Are there concerns that the included patients and setting do not match the review question?     Low concern
DOMAIN 2: Index Test (LACD)
Were the index test results interpreted without knowledge of the results of the reference standard? No    
If a threshold was used, was it pre‐specified? Yes    
Could the conduct or interpretation of the index test have introduced bias?   High risk  
Are there concerns that the index test, its conduct, or interpretation differ from the review question?     Low concern
DOMAIN 2: Index Test (Scheimpflug photography)
DOMAIN 2: Index Test (AS‐OCT)
DOMAIN 2: Index Test (SPAC)
DOMAIN 2: Index Test (Flashlight)
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition? Yes    
Were the reference standard results interpreted without knowledge of the results of the index tests? No    
Could the reference standard, its conduct, or its interpretation have introduced bias?   High risk  
Are there concerns that the target condition as defined by the reference standard does not match the question?     Low concern
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard? Yes    
Were all patients included in the analysis? Yes    
Did all patients receive a reference standard Yes    
Could the patient flow have introduced bias?   Low risk