Fig 1. Screening of household contacts of adult pulmonary TB patients in India.

Flowchart depicts the screening of household contacts (HHC) of adult pulmonary TB (PTB) patients in India, and shows that 1051 HHC enrolled in the study, 997 with no baseline TB disease (TBD) and with at least one baseline test for TB infection (TBI) available, were included in the final analysis. These 997 asymptomatic HHC were classified as those with and without baseline TBI (baseline TBI was defined as TST ≥ 5 mm and/or IGRA ≥ 0.35 IU/ml). HHC without baseline TBI were further classified as those with and without incident TBI (iTBI was defined as TST ≥ 5 mm and/or IGRA ≥ 0.35 IU/ml at follow up). Finally, the number of HHC who developed Incident TB disease (iTBD) was stratified by their TBI status.