Zavvar 2016.

Study characteristics
Methods	Study design: single‐centre RCT Country: Iran Setting: fertility clinic Sponsorship source: not disclosed Trials registry number: not disclosed
Participants	Inclusion criteria: women who produce only immature oocytes in spite of stimulation with gonadotropins Exclusion criteria: not disclosed Number of participants randomised to each arm of the study: 31 women were randomised to receive the intervention medium, and 45 were randomised to receive the control medium Group differences: not disclosed Fresh or frozen cycle?: not disclosed IVF or ICSI?: ICSI Length of time exposed to intervention medium: not disclosed Trade name and concentration of GM‐CSF in intervention medium: MediCult 2 ng/mL Trade name of control medium: not disclosed Day of embryo transfer: not disclosed Number of embryos transferred: not disclosed
Interventions	Intervention: GM‐CSF‐supplemented culture medium Control: standard IVF medium
Outcomes	Clinical pregnancy rate
Notes	First author contacted by email for further information on 26 November 2019 and 9 January 2020, but no response received.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No description of how random sequence was generated
Allocation concealment (selection bias)	Unclear risk	No description of how allocation was concealed
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Blinding was not mentioned.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Blinding of outcome assessors was not described.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	We assessed the study as at unclear risk, as we do not have access to number of dropouts or indeed how many participants were included in the analysis.
Selective reporting (reporting bias)	Unclear risk	No access to a protocol or a trial registry entry
Other bias	High risk	Small sample size of 76 participants