NCT01689428.

Methods	Prospective randomised controlled trial
Participants	100 infertile couples with an indication for standard IVF or intracytoplasmic sperm injection. All couples had at least a previous miscarriage and/or biochemical pregnancy experience after assisted reproductive technology (ART) treatment. Inclusion criteria: At least 1 (maximum 3) miscarriage and/or biochemical pregnancy after ART treatment Exclusion criteria: Frozen spermatozoa Frozen oocytes Women with polycystic ovaries (PCO) and polycystic ovarian syndrome (PCOS) Women with more than 4 ART treatments
Interventions	Intervention: embryo culture in EmbryoGen medium Control: embryo culture in ISM1 medium
Outcomes	Primary outcome measure: Ongoing pregnancy rate after 12 weeks of gestation [ Time Frame: 12 weeks after conception ] Secondary outcome measure: Ongoing implantation rate after 12 weeks of gestation [ Time Frame: 12 weeks after conception ]
Notes	Country of recruitment: Italy Unable to determine if women or oocytes were randomised