NCT01689454.

Methods	Described as both a prospective randomised controlled trial and an observational cohort study
Participants	Infertile couple with an indication for standard IVF or intracytoplasmic sperm injection. All couples had previous implantation failures after ART treatment (minimum 2, maximum 4 embryo replacements). Inclusion criteria: Women experiencing at least 2 (maximum 4) failures of implantation after ART treatments (with elective embryo transfer) Exclusion criteria: Frozen spermatozoa Frozen oocytes Women PCO and PCOS Women with previous pregnancy, miscarriage, or biochemical pregnancy
Interventions	Control: embryo culture in ISM1 medium Intervention: embryo culture in EmbryoGen medium
Outcomes	Ongoing pregnancy rate after 12 weeks of gestation Ongoing implantation rate after 12 weeks of gestation
Notes	Unable to determine if RCT or cohort study, as methods unclear