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. 2020 Jul 16;2020(7):CD013497. doi: 10.1002/14651858.CD013497.pub2

NCT02651285.

Methods Randomised parallel assignment trial
Participants 180 women aged 20 to 28 years
Inclusion criteria:
  • Infertility

  • Healthy condition

  • Good ovarian reserve (anti‐mullerian hormone (AMH) levels more than 1 μg/mL)


Exclusion criteria:
  • Chromosomal defects in the couple

  • Metabolic diseases (diabetes, etc.)

  • Other genetic diseases (thalassaemia, cystic fibrosis, etc.)

Interventions Intervention: granulocyte colony‐stimulating factor (G‐CSF) medium
Control: medium without G‐CSF
Outcomes Primary outcome measures:
  • Pregnancy rate [Time Frame: 12 months] The number of participants who become pregnant after in vitro fertilisation (IVF) where G‐CSF medium is used divided for the number of participants treated

  • Implantation rate [Time Frame: 12 months] The number of embryos implanted after IVF where G‐CSF medium is used divided for the number of embryos transferred


Secondary outcome measures:
  • Number of blastocysts developed [Time Frame: 12 months]. The number of blastocysts obtained after IVF where G‐CSF medium is used divided for the number of fertilised oocytes

Notes Emailed authors for more information 29 October 2019, 9 January 2020, and 28 January 2020, but received no reply.
Unsure of nature of study and whether oocytes or women were randomised

ICSI: intracytoplasmic sperm injection