Fig 10. The mechanism graph of the regulatory network and function of MAVS.

(A) Fish MAVS could induce the innate antiviral responses through recruiting NF-κB and IRF3 to trigger IFNs activation upon RNA viral infection. miR-122 targets MAVS and represses MAVS-mediated antiviral responses, thereby promoting viral replication. MARL act as a molecular sponge regulating miR-122 to enhance MAVS expression, thereby maintaining the stable of antiviral responses and ensuring appropriate inflammatory responses. (B) The ceRNA regulatory networks may exist wildly in vertebrate species.