Table 2. Reactions implemented in our models.

${\text{Ca}}^{2+}+\text{CaM}((\text{n}-1){\text{Ca}}^{2+})\underset{{\text{k}}_{\text{off}}^{\text{n}}}{\overset{{\text{k}}_{\text{on}}^{\text{n}}}{\rightleftharpoons }}\text{CaM}({\text{nCa}}^{2+})$

$\text{Ng}+\text{CaM}\left(0{\text{Ca}}^{2+}\right)\underset{{\text{k}}_{\text{off}}^{\text{ng}}}{\overset{{\text{k}}_{\text{on}}^{\text{ng}}}{\rightleftharpoons }}\text{CaM}\cdot \text{Ng}$

$\text{CaMKII}+\text{CaM}\left({\text{nCa}}^{2+}\right)\underset{{\text{k}}_{\text{off}}^{\text{CaMnCa}}}{\overset{{\text{k}}_{\text{on}}^{\text{CaMnCa}}}{\rightleftharpoons }}\text{CaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)$

$\text{CaMKII}\cdot \text{CaM}\left(\left(\text{n}-1\right){\text{Ca}}^{2+}\right)+{\text{Ca}}^{2+}\underset{{\text{k}}_{\text{off}}^{\text{KnCa}}}{\overset{{\text{k}}_{\text{on}}^{\text{KnCa}}}{\rightleftharpoons }}\text{CaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)$

$\text{CaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)+\text{CaMKII}\cdot \text{CaM}\left({\text{mCa}}^{2+}\right)\underset{{\text{k}}_{\text{off}}^{\text{CaMKII}}}{\overset{{\text{k}}_{\text{on}}^{\text{CaMKII}}}{\rightleftharpoons }}\text{CaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)\cdot \text{CaMKII}\cdot \text{CaM}\left({\text{mCa}}^{2+}\right)$

$\text{CaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)\cdot \text{CaMKII}\cdot \text{CaM}\left({\text{mCa}}^{2+}\right)\stackrel{{\text{k}}_{\text{p}}^{\text{CaMmCa}}}{\to }\text{CaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)\cdot \text{pCaMKII}\cdot \text{CaM}\left({\text{mCa}}^{2+}\right)$

$\text{pCaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)\underset{{\text{k}}_{\text{p},\text{on}}^{\text{CaMnCa}}}{\overset{{\text{k}}_{\text{p},\text{off}}^{\text{CaM}}}{\rightleftharpoons }}\text{pCaMKII}+\text{CaM}\left({\text{nCa}}^{2+}\right)$

${\text{PP}}_1+\text{pCaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)\stackrel{{\text{k}}_{\text{M}}}{\rightleftharpoons }{\text{PP}}_1\cdot \text{pCaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)\stackrel{{\text{k}}_{\text{cat}}}{\to }{\text{PP}}_1+\text{CaMKII}\cdot \text{CaM}\left({\text{nCa}}^{2+}\right)$

Listed are the reactions implemented in both models with the exception of the 5th reaction between 2 CaMKII monomers, that is only present in the mCaMKII model since in the hCaMKII model the the subunits are already linked to one another within the holoenzyme. Here n stands for the number and different configurations of Ca²⁺ ions bound to CaM (thus nCa²⁺ should be read as ‘aCbN’, where a and b can range from 0 to 2, see Table 1.)