Levy 1991.
Methods | Prospective randomised crossover study | |
Participants | George Washington University Medical Center, Washington, DC As stated in the abstract, 31 IVF‐ET candidates with regular ovulatory menstrual cycles and no male factor have enrolled thus far |
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Interventions | Natural cycle versus stimulated cycle IVF In the natural cycle, 4000 IU hCG was given in an effort to precede the endogenous LH surge In the stimulated cycle, luteal phase initiated GnRH suppression was followed by human menopausal gonadotropin (10.000 IU) administration |
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Outcomes | Pregnancy rates, cancellation rates, oocyte retrieval and fertilisation rate | |
Notes | Stated as ongoing. Attempts to contact any of the authors failed. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Does not state method of randomisation. No further information obtained |
Allocation concealment (selection bias) | Unclear risk | Method not stated |
Blinding of participants and personnel (performance bias) Objective outcomes | Low risk | The outcomes are not likely to be influenced by any lack of blinding |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | The outcome measurement is not likely to be influenced by any lack of blinding |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Thirty‐one patients included, 16 patients underwent natural cycle and 13 underwent the stimulated cycle; 2 patients are missing; 94% of participants included in analysis |
Selective reporting (reporting bias) | Unclear risk | No protocol available |
Other bias | Low risk | No other sources of bias were found |