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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: ACS Catal. 2019 Sep 17;9(11):9775–9788. doi: 10.1021/acscatal.9b02737

Scheme 2.

Scheme 2.

Engineered heme protein-catalyzed new-to-nature transformations: (a) synthesis of the cyclopropane core of antidepressant levomilnacipran;110 (b) enzymatic stereodivergent cyclopropanation of octene catalyzed by a suite of engineered cytochrome P411 proteins and globins.120