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. 2020 Jul 1;2020(7):CD012011. doi: 10.1002/14651858.CD012011.pub2

Devpura 2017.

Study characteristics
Methods Randomised controlled trial
Participants Inclusion criteria:
  1. All term > 37 weeks neonates born in hospital between November 2011 and October 2012 who satisfied the following criteria:

    1. Age > 24 hours and < 14 days

    2. Apgar score at 5 minutes > 6

    3. TSB < 357 μmol/L

    4. Neonates with ABO incompatibility but negative direct Coombs test (DCT) with no evidence of haemolysis on peripheral blood smear


Exclusion criteria:
  1. Hyperbilirubinaemia requiring exchange transfusion

  2. Evidence of haemolysis in peripheral blood film

  3. Rh haemolytic disease

  4. Positive DCT

  5. G6PD deficiency

  6. Major congenital malformations

  7. Culture‐positive sepsis

  8. Need for intensive care

  9. Conjugated hyperbilirubinaemia


Mean (SD) age in days at recruitment:
Intervention = 2.84 (0.53)
Control = 2.96 (0.70)
Mean (SD) birth weight in kg of participants:
Intervention = 2.78 (0.36)
Control = 2.79 (0.26)
Interventions Intervention
Experimental group:
Single phototherapy with white reflective plastic curtains on 3 sides
Control group:
Single‐surface phototherapy
Outcomes Fall in SB at the end of 12 hours, 24 hours
Rate of fall of serum bilirubin in first 12 hours and between 12 hours and 24 hours
Duration of phototherapy (hours)
Notes Study done at a tertiary care institution in Rajasthan, India. SB reported in mg/dL
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "...randomly assigned ... by paper chit method". We judged this description to show unclear risk
Allocation concealment (selection bias) Unclear risk Not reported
Blinding of participants and personnel (performance bias)
All outcomes High risk Participants: neonates by definition blinded, but parents not blinded. Clinicians/Nurses not blinded. The type of intervention may have influenced handling of the baby by parents and healthcare providers
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not reported. We judged bilirubin measurement to be an objective measurement not affected by lack of blinding
Incomplete outcome data (attrition bias)
All outcomes Low risk Three patients in the intervention group and 4 in the control group excluded from analysis (i.e. 6.5% of participants not included in analysis)
Selective reporting (reporting bias) Low risk Protocol not available. All expected outcomes reported
Other bias Low risk No other source of bias identified