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. 2020 Jul 1;2020(7):CD012011. doi: 10.1002/14651858.CD012011.pub2

Djokomuljanto 2006.

Study characteristics
Methods Randomised controlled trial
Participants Inclusion criteria:
  1. Conducted at a single centre in Malaysia

  2. Term newborns with uncomplicated neonatal jaundice presenting in the first week of life, with levels of bilirubin requiring phototherapy according to Malaysian CPG based on AAP guidelines


Exclusion criteria:
  1. Babies with serum bilirubin levels close to the exchange transfusion limit


Mean (SD) age in days at recruitment:
Intervention = 4.30 (2.08)
Control = 4.45 (2.07)
Mean (SD) body weight in kg of participants:
Intervention = 3.01 (0.49)
Control = 3.07 (0.44)
Interventions Single phototherapy with reflective curtains vs single phototherapy
Outcomes Mean decrease in SB after 4 hours phototherapy
Median duration phototherapy (hours)
Side effects including hypothermia, hyperthermia, dehydration, weight loss, skin rash, bronze discolouration
Notes Breastfeeding not reported. Study author contacted for mean SB at 24 hours and replied that this was not available
Study performed in Kelantan, Malaysia, from 1 September 2005 until 1 December 2005
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Block randomisation generated via computer software by a staff member who was not involved in the study (information provided by study authors)
Allocation concealment (selection bias) Low risk "The investigators were blinded to the allocation until the inclusion of the infant in the study had been confirmed"
Blinding of participants and personnel (performance bias)
All outcomes High risk Participants: neonates by definition blinded, but parents not blinded. Clinicians/Nurses not blinded. The type of intervention may have influenced handling of the baby by parents and healthcare providers
Blinding of outcome assessment (detection bias)
All outcomes Low risk "The laboratory staff were blinded to the study"; we judged bilirubin measurement to be objective. Lack of blinding of participants and staff unlikely to have an effect on the outcomes reported (changes in bilirubin levels)
Incomplete outcome data (attrition bias)
All outcomes Low risk Dropout rate < 5%
Selective reporting (reporting bias) High risk In the methods, stated that bilirubin levels taken after 4, 8, 16, and 24 hours, but only changes in levels after 4 hours reported
Other bias Low risk No other sources of bias identified