| Methods |
Randomised, double blind, placebo controlled, cross‐over trial |
| Participants |
3 children with epilepsy |
| Interventions |
ACTH 4‐9 |
| Outcomes |
25% to 50% reduction in overall seizure frequency in those on low dose,
in 50% of those on high dose |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Does not state how randomisation was achieved. |
| Allocation concealment (selection bias) |
Unclear risk |
Although a code is mentioned, no detail is given about this. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Researchers were blinded. |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Participants were blinded. |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
Outcome assessors were blinded. |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
Only 60% of randomised participants could be included in the analysis. Therefore, there was 40% missing data. |
| Selective reporting (reporting bias) |
Unclear risk |
Protocol of the study unavailable. |
| Other bias |
High risk |
Very low sample size (5 participants) and therefore it is unlikely that this study was adequately powered to detect statistical significance. |
