NCT02766465.

Study name	Bone Marrow Transplantation vs Standard of Care in Patients with Severe Sickle Cell Disease (BMT CTN 1503) (STRIDE2)
Methods	Quazi‐randomized controlled trial
Participants	Adolescents and young adults with severe SCD
Interventions	Hematopoietic cell transplant versus standard of care
Outcomes	Survival, changes in SCD‐related events (pulmonary hypertension, cerebrovascular events, renal function, avascular necrosis, leg ulcer) and functional outcomes (6MWD, health‐related quality of life, cardiac function, pulmonary function, and mean pain intensity) Additionally for those assigned to the donor arm, the trial will assess hematopoietic recovery, graft rejection, acute and chronic graft‐versus‐host disease, other significant transplant‐related complications and disease‐free survival
Starting date	November 2016
Contact information	Medical College of Wisconsin
Notes

SCD: sickle cell disease
6MWD: 6‐minute walk distance