Miller 2000.

Methods	Frankfurt cohort N=48 Non Randomized Open fup: reported w/o: reported
Participants	Eligibility: Median ART =9 drugs (4‐13) AZT/3TC98% d4T/DDI SQV 84% IDV 88% NVP 72% RTV 65% ZCT Baseline CD4 =155 (2‐777) Baseline VL =5.07(2.7‐6.7)
Interventions	121 days(54‐322 days) TI
Outcomes	STI gp: CD4 decline: 89 cells/microlitre (p=0.0001); VL rebound: 0.7 log copies/ml ( p=0.0001); Reversion: 28/45 participants Model predictors of TI : 1. CD4 cell OR 2.32; 2. prior ART OR=0.66;
Notes	Predictors of genotypic shift: 1. CD4 cell count, 2. ARV duration
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	D ‐ Not used