Singer 2006.

Methods	OPTIMA trial N=504 Randomized Open label fup: 24 weeks w/o: reported
Participants	Eligibility:‐ VL>2,500 cop/ml CD4<300 Age>18 yrs Failure two drug classes On ART for 3 months HIV serologic diagnosis
Interventions	3 months STI
Outcomes	CD4>200: 8% participants CD4 51‐200: 14% participants CD4 <50: 46% participants VL: 1 log reduction in (54% ARDFP) participants Model predictors for AIDS events: 1.CD4 salvage therapy ( HR 0.874) 2. VL at 24 wks (HR 1.81)
Notes	Preliminary report on an ongoing trial. Predictors of AIDS:‐ 1.CD4 at salvage therapy, 2. changes in CD4, VL, 24 weeks after onset of therapy.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate