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. 2006 Jul 19;2006(3):CD006148. doi: 10.1002/14651858.CD006148

Walmsley 2005.

Methods CTN 164 trial 
 N=134 
 Randomized 
 Open label 
 fup: 60 weeks 
 w/o: reported
Participants Eligibilty :‐ 
 VL>1,000 cop/ml 
 2 ART remaining in salvage regimen, 
 Baseline CD4 343 cells/mm3 
 Baseline VL 3.9 log copies/ml,. 
 Baseline ART: PI + NRTI + NNRTI
Interventions 12 wks STI
Outcomes CD4 decline: 132 cells/mm3; 
 VL increase: 2.7 log copies/ml,
Notes Genotypic shift predicted by nadir CD4;
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Low risk A ‐ Adequate