Brown 2004.

Methods	OPTIMA trial N=289 Randomized Open label fup: 24 weeks w/o: reported
Participants	Eligibility:‐ VL>2,500 cop/ml CD4<300 Age>18 yrs Failure two drug classes On ART for 3 months HIV serologic diagnosis
Interventions	3 months STI
Outcomes	Differences between STI and control arms: Events: Greater Non serious AIDS events than AIDS events in STI arm. Quality of life: no differences between arms
Notes	Currently ongoing trial
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate