Table 6 –

Correlation analyses for baseline characteristics and modeling parameters.

Variable	Group		Obs	kt	Ktissue	φ	OFC	pv
Age	Control	r	10	0.52	−0.24	0.36	0.27	0.18
		p-value		0.12	0.51	0.31	0.44	0.62
	PAD	r	10	−0.05	−0.29	−0.26	0.12	−0.08
		p-value		0.89	0.43	0.46	0.74	0.83
	Average	r	20	0.42	0.41	−0.3	0.04	0.24
		p-value		0.06	0.07	0.21	0.86	0.31
Body mass index	Control	r	10	0.06	−0.16	0.03	0.18	−0.03
		p-value		0.86	0.67	0.95	0.62	0.93
	PAD	r	10	−0.14	−0.13	−0.15	0.12	−0.02
		p-value		0.70	0.72	0.68	0.74	0.95
	Average	r	20	0.10	0.17	−0.24	0.09	0.08
		p-value		0.67	0.47	0.30	0.72	0.75
Ankle brachial index (rest)	Control	r	5	0.94	0.86	0.72	0.17	0.26
		p-value		0.017	0.06	0.17	0.78	0.67
	PAD	r	10	−0.05	0.27	0.45	−0.18	−0.01
		p-value		0.88	0.45	0.19	0.61	0.97
	Average	r	15	−0.39	−0.42	0.64	0.04	−0.22
		p-value		0.15	0.12	0.011	0.88	0.42
Ankle brachial index (exercise)	Control	r	5	0.33	−0.28	−0.31	0.82	−0.69
		p-value		0.58	0.64	0.61	0.09	0.19
	PAD	r	7	0.22	0.72	0.57	−0.44	0.15
		p-value		0.63	0.07	0.18	0.32	0.75
	Average	r	12	−0.3	−0.36	0.72	−0.18	−0.28
		p-value		0.34	0.25	0.008	0.57	0.38
Δ of Ankle brachial index	Control	r	5	−0.49	−0.86	−0.77	0.44	−0.69
		p-value		0.40	0.06	0.13	0.46	0.2
	PAD	r	10	0.30	0.29	−0.02	0.08	0.46
		p-value		0.40	0.42	0.95	0.82	0.18
	Average	r	15	−0.04	−0.2	0.20	0.19	0.20
		p-value		0.89	0.48	0.49	0.50	0.48
eGFR	Control	r	5	0.13	−0.04	−0.07	0.20	−0.09
		p-value		0.84	0.95	0.91	0.75	0.89
	PAD	r	10	0.33	0.50	0.39	−0.15	0.45
		p-value		0.34	0.14	0.26	0.68	0.19
	Average	r	15	0.24	0.27	0.33	−0.11	0.38
		p-value		0.38	0.33	0.24	0.70	0.17
Hypertension	Control	r	5	−0.89	−0.65	−0.44	−0.35	0.02
		p-value		0.042	0.23	0.46	0.56	0.97
	PAD	r	10	−0.10	0.05	0.05	0.16	−0.02
		p-value		0.79	0.89	0.90	0.65	0.95
	Average	r	15	0.15	0.43	−0.32	−0.08	0.16
		p-value		0.58	0.11	0.25	0.77	0.57

k^t is the transfer rate constant; K_tissue is the interstitial permeability; φ is the porosity; OFC is the outflow filtration coefficient; p_v is microvascular pressure.

eGFR: estimated glomerular filtration rate.