2. Percentage deaths (remission‐inducing studies).

Study	Comparison	Rx 1	Rx 2 /control
Brecher 1997	Prespecified duration (1) versus duration determined by clinical response (2).	29	21
Olweny 1976	C: 40 mg/kg IV on day 1,repeated after 2 weeks or as soon as toxicity is abated (1) versus C: 30 mg/kg IV on day 1; O: 2 mg/m2 IV on day 1; MTX: 15 mg/m2 orally on days 1 to 3. This is repeated 12 to 14 days later (2).	58	33
Patte 1991	Long‐duration chemotherapy (1) versus short‐duration chemotherapy (2).	10	12
Ziegler 1972a	C (1) versus TRIKE (2).	50	28

C: cyclophosphamide 
 IV: intravenous 
 MTX: methotrexate 
 O: oncovin (vincristine)