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| Study | Comparisons | Rx1 | Rx2/ control | Type of toxicity |
| Brecher 1997 | Prespecified duration (1) versus duration determined by clinical response (2) | 74 | 96 | Grades 3 and 4 toxicity; haematologic, neurotoxic, infections. |
| Patte 1991 | Long‐duration chemotherapy (1) versus short‐duration chemotherapy (2) | 0 | 4 | Haematologic, multi‐organ failure, infections. |
| Patte 2007 | 1A versus 1B and 2A versus 2B | Infections and stomatitis (graded 1 to 4). |
