Neequaye 1990.
Methods | Randomised, parallel group, single‐centre study (Ghana). Method of randomisation: "assigned by a randomised numbered list". Allocation concealment: unclear. Blinding: no. ITT: unclear. Withdrawals: stated. | |
Participants | Baseline characteristics: 46 participants screened and given 3 courses of C (27 children randomised (male:female: 16:11)).
Median age: 9 years.
Tumour staging: unclear.
Diagnosis: histopathology. Entry criteria: stage III BL; adequate response to C. Exclusion criteria: not reported. |
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Interventions | Monthly intramuscular TF versus no treatment. Trial was stopped prematurely due to exhausted stocks of intervention agent. Study duration: maximum of one year. Follow‐up: median 3.3 years. |
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Outcomes | Relapse. Overall survival. | |
Notes | Full text publication. Study type: remittance maintenance. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Randomised number list. |
Allocation concealment (selection bias) | Unclear risk | Not described. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Not described. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Late failures rates were accounted for. |