Olweny 1977.
Methods | Randomised, parallel group, single‐centre trial (Kenya). ITT: no. Withdrawals: stated. | |
Participants | Baseline characteristics: 25 participants randomised; 22 participated.
Median age: irradiation: 8 years; no irradiation: 5 years (range: 4 to 14).
Tumour staging: Ziegler and Magrath.
Diagnosis: histology or cytology. Entry criteria: BL free of CNS involvement in remission post treatment with C, MTX, or O. |
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Interventions | Irradiation versus no irradiation. Dose given was 20 to 24 Gy (0.7 to 0.75 Gy per fraction). Treatment duration: 2 x 5 days. Follow‐up: 1.6 years. |
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Outcomes | Relapse. Overall survival. | |
Notes | Full text publication. a follow‐up on Olweny 1976. Study type: remittance maintenance. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Stated as "previously prepared random cards". |
Allocation concealment (selection bias) | Unclear risk | Not described. |
Blinding (performance bias and detection bias) All outcomes | High risk | The authors made adjustments for the number that were unable to make the trip to the treatment venue. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Outcomes were described for all participants. |