Sullivan 1991.
Methods | Randomised, parallel group, multicentre trial (North America). ITT: unclear. Withdrawals: stated. | |
Participants | Baseline characteristics: 168 participants registered, 148 were evaluable, 73 had BL.
Median age: 8.7 years (range 0.7 to 18.7), male:female; 4.4:1.0.
Tumour staging: Murphy.
Diagnosis: unclear (institutional review). Entry criteria: stages III and IV non lymphoblastic NHL, age < 22 years. Exclusion criteria: not stated. |
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Interventions | Triple IT (Ara‐C, MTX, HYD) given for short (2 months) versus long (6 months) term as maintenance treatment. Follow‐up: 3 to 7 years. |
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Outcomes | Complete remission. Event‐free survival. Toxicity. | |
Notes | Full text publication. Study type: remission induction. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described. |
Allocation concealment (selection bias) | Unclear risk | Not described. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Not described. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Outcomes described |