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. 2020 Jul 23;11(4):1009–1020. doi: 10.14336/AD.2019.0920

Figure 1.

Figure 1.

Model for biogenesis of CDR1as. In humans, CDR1 gene is located in the sex chromosome site: chrXq27.1 (140783260-140784558), gene ID: 1038 (www.ncbi.nlm.nih.gov/gene/1038), and CDR1 gene is encoded by a single exon without introns [32]. In humans, LINC00632 gene is located in the sex chromosome site: chrXq27.1 (140709759-140772677), gene ID: 286411, and encoded by five exons (www.ncbi.nlm.nih.gov/gene/?term=linc00632). Barrett discovered that the promoters of LINC00632 are responsible for driving CDR1as expression and that the CDR1as sequence is embedded in LINC00632 locus [31]. We speculate the pre-linear RNA of CDR1as is transcribed by the antisense strand of CDR1, which is followed by back-splicing of the 5' and 3' ends to form the circular RNA.