TABLE 1.
Clinical characteristics and outcomes of patients undergoing pleurectomy for mesothelioma
| All patients (n = 93) | VTE (n = 30) | No VTE (n = 63) | P value | 95% CI | |
|---|---|---|---|---|---|
| Age, y, median (range) | 71 (30–85) | 70 (52–82) | 72 (30–85) | .34 | −2.3 to 5.2 |
| Gender, male, n (%) | 74 (80) | 25 (83) | 49 (78) | .59 | −0.11 to 0.22 |
| Caprini score, mean ± SD | 12 ± 1 | 11 ± 1 | 12 ± 1 | <.001* | 1.0 to 1.9 |
| IOHC, n (%) | 59 (63) | 21 (70) | 38 (60) | .49 | −0.11 to 0.30 |
| Neoadjuvant chemotherapy, n (%) | 15 (16) | 4 (13) | 11 (17) | .76 | −0.20 to 0.11 |
| Histology, n (%) | |||||
| Epithelioid | 60 (65) | 19 (63) | 41 (65) | ||
| Sarcomatoid | 4 (4) | 2 (67) | 2 (3) | - | - |
| Biphasic | 29 (31) | 9 (30) | 20 (32) | ||
| Patients with complications, n (%) | 72 (77) | 25 (83) | 47 (74) | .43 | −0.08 to 0.26 |
| Transfusion (n%) | 30 (32) | 12 (40) | 18 (29) | .27 | 0.60 to 1.1 |
| Epidural catheter (n%) | 88 (95) | 30 (100) | 58 (92) | .33 | 0.67 to 0.82 |
| Hematologic complications, n (%) | 9 (10) | 5 (17) | 4 (6) | .14 | −0.04 to 0.25 |
| Postoperative LOS | 15 (4–85) | 17 (6–40) | 14 (4–85) | .18 | −6.0 to 1.0 |
| Distribution of VTE | |||||
| VTE, n (%) | 30 (100) | ||||
| DVT, n (%)† | 27 (90) | ||||
| Asymptomatic | 9 (33) | ||||
| Upper extremity | 12 (44) | ||||
| Indwelling catheter | 7 (58) | ||||
| Lower extremity‡ | 18 (67) | ||||
| Proximal | 2 (11) | ||||
| Distal | 17 (94) | ||||
| PE, n (%) | 10 (33) |
Boldface emphasizes the denominator of 30. VTE, Venous thromboembolism; CI, confidence interval; SD, standard deviation; IOHC, intraoperative heated chemotherapy; LOS, length of stay; DVT, deep vein thrombosis; PE, pulmonary embolism.
*
Statistically significant.
†
Three patients had both upper- and lower-extremity DVTs.
‡
Four patients had both proximal and distal lower-extremity DVTs.