Table 1. Demographic data for enrolled infants with culture-proven bacterial meningitis and uninfected infants without meningitis.
P values were calculated with Graphpad Prism 7 using the Mann-Whitney U test, Chi-square, or Fisher’s exact test, as applicable. BM: bacterial meningitis, IQR: interquartile range, VP: ventriculo-peritoneal, WBC: white blood cell count, RBC: red blood cell count.
| Variables | BM (N=19) | Uninfected (N=19) | p |
|---|---|---|---|
| Gestational age, weeks+days, median (IQR) | 35w6d (27w0d-38w0d) | 35w0d (26w5d-38w0d) | >0.99 |
| Postnatal age, days, median (IQR) | 40 (21-57) | 44 (30-65) | 0.86 |
| Birthweight, grams, median (IQR) | 2211 (905-3160) | 2210 (640-3090) | 0.73 |
| Preterm (<37 weeks gestation), n (%) | 13 (68%) | 13 (68%) | >0.99 |
| Male sex, n (%) | 11 (58%) | 13 (68%) | 0.74 |
| Race/Ethnicity, n (%) | 0.78 | ||
| Black, non-Hispanic | 8 (42%) | 6 (32%) | |
| White, non-Hispanic | 9 (47%) | 11 (58%) | |
| Other (Hispanic, Asian, or unknown) | 2 (11%) | 2 (10%) | |
| VP shunt or Ommaya reservoir, n (%) | 9 (47%) | 1 (5%) | 0.0078 |
| Culture-proven bacteremia, n (%) | 7 (37%) | 2 (10%) | 0.12 |
| CSF WBC (cells/mm3), median (IQR) | 215 (57-923) | 2 (0-4) | <0.0001 |
| CSF Glucose (g/dL), median (IQR) | 31 (20-46) | 52 (42-64) | <0.0001 |
| CSF Protein (g/dL), median (IQR) | 317 (171-709) | 76 (43-122) | <0.0001 |
| CSF RBC (cells/mm3), median (IQR) | 124 (29-2870) | 15 (3-623) | 0.042 |
| Greater than 500 cells/mm3 RBC, n (%) | 9 (47%) | 5 (26%) | 0.19 |