Table 2.
Top 10 altered pathways associated with the 17 genes with CNAs in Ghanaian invasive carcinomas obtained using enrichment analysis using GO annotation (REACTOME).
| GO Term | Biological Process | FDR | Genes |
|---|---|---|---|
| HSA-453279 | Mitotic G1–G1/S phases | 0.0015 | ABL1,AKT3,CCND1,CCNE1 |
| HSA-212436 | Generic Transcription Pathway | 0.002 | ABL1,AKT3,CCND1,CCNE1, DEK,G6PD,SMARCA4 |
| HSA-8849470 | PTK6 Regulates Cell Cycle | 0.002 | CCND1,CCNE1 |
| HSA-199418 | Negative regulation of the PI3K/AKT network | 0.0023 | AKT3,FGF3,PDGFRA |
| HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.0023 | AKT3,FGF3,PDGFRA |
| HSA-69202 | Cyclin E associated events during G1/S transition | 0.0023 | AKT3,CCND1,CCNE1 |
| HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.0023 | AKT3,CCND1,CCNE1 |
| HSA-8878166 | Transcriptional regulation by RUNX2 | 0.0028 | ABL1,AKT3,CCND1 |
| HSA-109606 | Intrinsic Pathway for Apoptosis | 0.0108 | AKT3,BCL2L1 |
| HSA-3214858 | RMTs methylate histone arginines | 0.0108 | CCND1,SMARCA4 |