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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Semin Cancer Biol. 2020 Jan 30;67(Pt 2):159–170. doi: 10.1016/j.semcancer.2020.01.012

Table 2.

Ubiquitylation-mediated degradation of cyclin D1

Enzymes Cell Lines Cell Cycle Phosphorylation-dependency References
E3 ubiquitin ligase
Fbxo4 NIH3T3, MEFs, U2OS, MCF-7, TE8, TE10, TE15, 451Lu, WM793B, 1205Lu G1-S Phospho-Thr286 mediated by GSK-3β [87, 94, 95, 107, 117]
Fbxw8 HCT116, SW480, T98G G1-S Phospho-Thr286 mediated by MAPK/Erk [98]
Fbxo31 SK-MEL-28 G1-S Phospho-Thr286 mediated by MAPK/Erk [104]
β-TrCP LNCaP G1-S Phospho-Thr286 mediated by IKKα [105]
APC/C MCF-7, MEFs — Phospho-Thr286 mediated by GSK-3β [106]
Deubiquitinase
USP2 HCT116, MCF-7, U2OS, PC3, 3T3-L1 G1-S — [137, 139]
USP22 HCT116, MCF-7, U2OS, PC3, H1299, 2091 G1-S Not depending on Thr286 phosphorylation [143]