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. Author manuscript; available in PMC: 2021 Aug 10.
Published in final edited form as: Neuroscience. 2020 Jun 13;441:33–45. doi: 10.1016/j.neuroscience.2020.06.009

Table 1. ECM-receptor interaction and AKT pathway perturbation by VPS35 D620N.

RNA-Seq was performed on WT and VPS35 D620N-expressing SH-SY5Y cells. The top 5 pathways affected by VPS35 D620N expression and relevant significance values are listed.

Pathway name Pathway ID p-value p-value (FDR) p-value (Bonferroni)
Pathways in cancer 05200 9.878e-8 2.683e-5 2.914e-5
Systemic lupus erythematosus 05322 1.819e-7 2.683e-5 5.367e-5
ECM-receptor interaction 04512 2.294e-6 2.256e-4 6.768e-4
PI3K-AKT signaling pathway 04151 3.124e-6 2.304e-4 9.215e-4
Focal adhesion 04510 9.627e-6 5.680e-4 0.003