Table 1. Baseline characteristics and laboratory findings according to FLI quartiles.
FLI quartile | p value | p for trend | p value between groups | ||||||
---|---|---|---|---|---|---|---|---|---|
Q1 | Q2 | Q3 | Q4 | ||||||
Baseline characteristics | |||||||||
Age (years) | 37.0±11.6 | 42.3±12.5 | 44.4±12.6 | 43.4±11.5 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Male (sex) | 12,831 (15.4) | 32,489 (38.9) | 49,372 (59.1) | 66,646 (79.7) | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Height (cm) | 161.3±7.1 | 163.2±8.9 | 165.3±9.4 | 168.5±8.5 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Weight (kg) | 52.1±6.1 | 58.9±7.3 | 65.2±8.3 | 74.8±10.4 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
BMI (kg/m2) | 20.0±1.8 | 22.1±1.8 | 23.8±2.1 | 26.3±2.8 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Waist circumference (cm) | 67.9±4.9 | 74.9±4.8 | 80.5±5.1 | 87.6±6.5 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
SBP (mmHg) | 110.9±11.1 | 115.4±11.1 | 118.6±10.6 | 121.8±10.0 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
DBP (mmHg) | 69.4±7.9 | 71.9±8.0 | 73.9±7.6 | 76.3±7.1 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Smoking | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||||||
Non-smoker | 70,753 (84.7) | 58,768 (70.3) | 47,115 (56.4) | 31,578 (37.8) | |||||
Ex-smoker | 3,928 (4.7) | 7,261 (8.7) | 11,548 (13.8) | 15,162 (18.1) | |||||
Current smoker | 8,877 (10.6) | 17,547 (21.0) | 24,908 (29.8) | 36,835 (44.1) | |||||
Alcohol consumption | |||||||||
Amount (g/wk) | 31.1±76.6 | 48.3±101.0 | 71.6±127.9 | 120.0±173.0 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Activity (met-min/wk) | 346.2±351.5 | 379.2±383.3 | 388.0±389.0 | 373.8±374.9 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Laboratory findings | |||||||||
Hemoglobin (g/dL) | 13.0±1.4 | 13.5±1.6 | 14.1±1.6 | 14.8±1.4 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Fasting glucose (mg/dL) | 87.9±9.5 | 90.3±10.2 | 92.2±10.8 | 94.8±11.4 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Total cholesterol (mg/dL) | 177.0±34.0 | 187.3±35.8 | 196.5±39.1 | 207.0±40.3 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
Triglyceride (mg/dL) | 62.7±22.6 | 88.2±34.0 | 119.9±53.5 | 196.7±130.7 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
HDL cholesterol (mg/dL) | 64.1±24.4 | 59.3±20.0 | 55.6±26.1 | 51.7±32.0 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
LDL cholesterol (mg/dL) | 109.0±247.6 | 113.7±141.8 | 121.2±129.3 | 122.5±124.7 | <0.001 | <0.001 | *, †, ‡, §, ∥ | ||
Creatinine (mg/dL) | 0.9±1.0 | 1.0±1.1 | 1.0±1.2 | 1.1±1.2 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ | ||
GFR (mL/min/1.73m2) | 90.1±28.1 | 90.0±28.3 | 92.2±28.9 | 99.3±30.6 | <0.001 | <0.001 | †, ‡, §, ∥, ¶ | ||
GGT (U/L) | 14.2±5.6 | 19.1±9.9 | 27.9±20.3 | 59.7±61.8 | <0.001 | <0.001 | *, †, ‡, §, ∥, ¶ |
Data are shown as mean±standard deviation or number (%).
BMI = body mass index; DBP = diastolic blood pressure; FLI = fatty liver index; GFR = glomerular filtration rate; GGT = gamma-glutamyl transferase; HDL = high-density lipoprotein; LDL = low-density lipoprotein; SBP = systolic blood pressure.
*p value less than <0.05 between Q1 and Q2; †p value less than <0.05 between Q1 and Q3; ‡p value less than <0.05 between Q1 and Q4; §p value less than <0.05 between Q2 and Q3; ∥p value less than <0.05 between Q2 and Q4; ¶p value less than <0.05 between Q3 and Q4.