Table 1.
Comparison of AAV Transduction Efficiency in the Inner Ear
| Cell Types |
Cochlear Hair Cells |
Vestibular Hair Cells | Spiral Ganglion Neurons | References | |
|---|---|---|---|---|---|
| Stage-AAV | IHCs | OHCs | |||
| In utero-Anc80L65 | 91%–97% | 84%–94% | 92.6% | 96.7% | This study |
| In utero-AAV1 | 89%–91% | 84%–92% | ND | ND | Kim et al., 201631 |
| Newborn-Anc80L65 | ~100% | 81%–95% | ND | ND | Gu et al., 201918 |
| ~100% | 90%–100% | ~83% | ND | Landegger et al., 20173 | |
| ~94% | ~67% | ~67.7% | ND | Isgrig et al., 20197 | |
| ND | 80%–100% | ND | ND | Pan et al., 201713 | |
| Adult-Anc80L65 | 84%–98% | 2.5%–71% | ND | ND | Tao et al., 201815 |
| ~100% | 18%–90% | ~38% | 3%–10% | Suzuki et al., 201716 | |
| 84%–91% | ND | ND | ND | Yoshimura et al., 201817 | |
ND, not described.