Fig. 2.

Effects of locally-injected S-(2-aminoethyl) isothiourea (AE-ITU) or N^G-nitro-l-arginine (L-NNA) on rat carrageenan (Cg)-induced pleurisy and nitrite/nitrate (NOx) levels. (A–C) AE-ITU, L-NNA, or vehicle (saline) was injected directly into the pleural cavity immediately prior to intrapleural Cg injection. The effects of the treatments on NOx level (A), exudate volume (B), and cell number (C) in pleural exudates were evaluated 6 h after Cg challenge. Horizontal axes: doses (mg/kg) of AE-ITU and L-NNA. Cg indicates control animals injected with saline prior to Cg injection. Data are expressed as mean ± SEM (n = 6–8 rats). *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. Cg.