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. 2020 Jul 24;23:100790. doi: 10.1016/j.bbrep.2020.100790

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 6 — Effects of locally-injected hemin, carbon monoxide releasing molecule-3 (CORM-3), or inactive carbon monoxide releasing molecule-3 (iCORM-3) on rat carrageenan (Cg)-induced pleurisy. (A, B) Hemin, CORM-3, iCORM-3, or vehicle (NaOH) was injected directly into the pleural cavity immediately prior to intrapleural Cg injection. The effects of the treatments on exudate volume (A) and cell number (B) in pleural exudates were evaluated 6 h after Cg challenge. Horizontal axes: doses (mg/kg) of hemin, CORM-3, and iCORM-3. Cg indicates control animals injected with vehicle prior to Cg injection. Data are expressed as mean ± SEM (n = 5–7 rats). *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. Cg. ⁺⁺, P < 0.01; ⁺⁺⁺, P < 0.001 vs. iCORM-3.