Table 1.
Effects of local nitric oxide inhibition or induction on myeloperoxidase activity and antioxidant enzyme activities in the pleural exudates from 6 h post-carrageenan challenge.
| Group | MPOa (mU/ml) | CATb (mmol/min/ml) | SODc (USOD/ml) | GPxd (μmol/min/ml) | GSTe (μmol/min/ml) |
|---|---|---|---|---|---|
| Saline | 73.1 ± 3.8 | 11.5 ± 1.0 | 82.8 ± 1.5 | 1.54 ± 0.09 | 30.4 ± 1.6 |
| Vehiclef + Cgg | 295.8 ± 8.1 *** | 34.5 ± 1.3 *** | 115.4 ± 3.0 *** | 3.52 ± 0.10 *** | 106.4 ± 1.6 *** |
| L-NNAh + Cg | 387.9 ± 11.2 ***, ### | 46.5 ± 2.8 ***, ### | 153.2 ± 6.3 ***, ### | 4.41 ± 0.21 ***, ## | 144.4 ± 3.8 ***, ### |
| AE-ITUi + Cg | 405.9 ± 10.3 ***, ### | 45.0 ± 1.3 ***, ### | 160.8 ± 5.2 ***, ### | 4.42 ± 0.11 ***, ### | 150.1 ± 2.9 ***, ### |
| l-arginine + Cg | 181.4 ± 6.0 ***, ### | 14.9 ± 0.6 ### | 60.1 ± 4.0 **, ### | 3.00 ± 0.21 | 50.4 ± 1.7 ***, ### |
| NOC-18 + Cg | 174.0 ± 6.5 ***, ### | 22.4 ± 1.7 ***, ### | 51.9 ± 3.5 ***, ### | 2.89 ± 0.19 *, # | 51.2 ± 2.0 *, ### |
Each value represents the mean ± SEM of 6–10 rats. *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. saline controls. #, P < 0.05; ##, P < 0.01; ###, P < 0.001 vs. vehicle + Cg.
a
MPO, myeloperoxidase activity.
b
CAT, catalase activity.
c
SOD, superoxide dismutase activity.
d
GPx, glutathione peroxidase activity.
e
GST, glutathione S-transferase activity.
f
Vehicle, saline.
g
Cg, carrageenan.
h
L-NNA, NG-nitro-l-arginine.
i
AE-ITU, S-(2-aminoethyl) isothiourea.